ANR NSC

You are here

UMR CNRS 6226 "Institut des Sciences Chimiques de Rennes", Université de Rennes 1

Address

UMR CNRS 6226, Institut des sciences chimiques de Rennes
Université de Rennes 1
263, avenue du Général Leclerc - Campus de Beaulieu - Bâtiment 10B
35042 RENNES Cedex
France

Description

Partner 4 (P4) (A. Bondon, L. Mouret) from the unit UMR CNRS 6226, Institut des Sciences Chimiques de Rennes, Université de Rennes 1, has experience in the NMR studies of neuropeptides, packing default sensor peptides and antimicrobial peptides. These peptides are investigated both in terms of structure and interaction with various partners, among them the small unilamellar vesicles (SUVs). Phospholipidic bilayers constitute the best membrane model. For molecules fully embedded inside the membrane the use of solid state NMR is relevant whereas in case of very strong dynamic behaviour NMR in liquid state can be performed. This behaviour is expected in the case of neuropeptides which are in general devoid of any folding in water and acquire defined structure in close contact to the membrane. Partner 4 has already demonstrated the efficiency of NMR in liquid state using SUVs for structural studies of several peripheral membrane peptides. All the experiments are performed using the facilities from the NMR component of the PRISM platform (Plate-forme Rennaise d’Imagerie et de Spectroscopie Multi-modales, “http://prism.irstea.fr”.