My research project focuses on the development and data mining of genomic, transcriptomic and peptidomic resources in a bivalve mollusk model, the cupped oyster Crassostrea gigas. This species of economic interest, by belonging to the clade of Lophotrochozoa is also, in a comparative context, an interesting model for addressing the evolution of neuroendocrine systems in bilaterian. In this perspective, after the recent structural identification of a majority of neuropeptides expressed in C. gigas, my work now centers on the functional characterization of receptor / ligand couples through the application of reverse endocrinology methodologies. This should lead to the characterization of new physiologically relevant regulator systems in mollusks and give insights into the origin and the evolution of certain neuroendocrine regulatory pathways.
BIGOT L, ZATYLNY-GAUDIN,C, RODET F, BERNAY B, BOUDRY P, FAVREL P.(2012) "Characterization of GnRH-related peptides from the Pacific oyster Crassostrea gigas." Peptides 34(2):303-310.
DHEILLY N.M., LELONG C., HUVET A., KELLNER K., DUBOS M.P., RIVIERE G., BOUDRY P., FAVREL P. (2012). Gametogenesis in the Pacific Oyster Crassostrea gigas: a microarrays-based analysis identifies sex and stage specific genes. Plos One ; 7(5):e36353
BIGOT L, BEETS I, DUBOS MP, BOUDRY P, SCHOOFS L, FAVREL P (2014) Functional characterization of a short neuropeptide F-related receptor in a Lophotrochozoa, the mollusk Crassostrea gigas. J Exp Biol. 21, 2974-82
Stewart MJ and Favrel P, Rotgans BA, Wang T, Zhao M, Sohail M, O’Connor WA, Elizur A, Henry J, Cummins SF. (2014) Neuropeptides encoded by the genomes of the Akoya pearl oyster Pinctata fucata and Pacific oyster Crassostrea gigas: a bioinformatic and peptidomic survey. BMC Genomics. 15:840
ZATYLNY-GAUDIN C, FAVREL P. (2014) Diversity of the RFamide Peptide Family in Mollusks. Front Endocrinol (Lausanne) 5:17